Nephrogenic diabetes insipidus mechanism
Megjelenés éve: Kivonat: Body fluid homeostasis is essential for normal life.
In the maintenance of water balance, the most important factor and regulated process is the excretory function of the kidneys. The kidneys are capable to compensate not only the daily fluctuations of water intake but also the consequences of fluid loss respiration, perspiration, sweating, hemorrhage.
The final volume and osmolality of the excreted urine is set in the collecting duct via hormonal regulation. The hormone of water conservation is the vasopressin AVPand a large volume of urine is produced and excreted in the absence of AVP secretion or if AVP is ineffective in the kidneys.
The aquaporin-2 water channel AQP2 is expressed in the principal cells, and it plays an essential role in the reabsorption of water in the collecting ducts via type 2 vasopressin receptor V2R -mediated mechanism. The DI is characterized by excessive production of hyposmotic urine "insipidus" means tasteless due to the inability of the kidneys to concentrate urine.
In this chapter, we focus and discuss the pathophysiology of nephrogenic DI NDI and the potential therapeutic interventions in the light of the current experimental data.