We hypothesized that endogenous PKC-dependent phosphorylation of the dominant inhibitory G protein in neurons, Go is selectively increased in dorsal root ganglia DRGs from diabetic rats and associated with impaired regulation of calcium channels.
Studies were performed in DRGs from streptozotocin-induced diabetic rats with documented neuropath;,' diabetic for wks and age-matched controls. Immunoprecipitation was detected by immunoblotting for the presence of a 39kDa phosphorylated species.
Basal labeling of Goa in controls 0. In summary, diabetic sensory neuropathy is associated with selective increased endogenous PKC-dependent phosphorylation of the Goa subunit that may contribute to impaired inhibition of calcium channels resulting in increased calcium influx. Ammar Quobatari, John W. The pathogenesis of diabetic diabetes therapy journal neuropathy is unresolved.
Previous studies suggest that a long-term consequence of diabetic neuropathy includes the loss of neurons. We examined the hypothesis that diabetic enteric neuropathy is associated with activation of programmed cell death or apoptosis.
Methods: Milgamma összetevői were performed on healthy age-matched controls, insulin treated and untreated streptozotocin-induced diabetic rats diabetic for weeks with documented neuropathy. Two hundred neurons were counted in a blinded manner and the percent of apoptotic neurons assessed.
Tablet. diabetes mellitus
After 4 weeks of diabetes some animals were treated with Linplant insulin implants 0. Apoptosis was 0. OI and 2. Conclusion: These studies suggest that activation of the can diabetic gastroparesis be reversed cascade occurs relatively early in diabetes, can be partially reversed by short-term insulin treatment and may contribute to the pathophysiology of diabetic enteric neuropathy.
Our aim was to evaluate the characteristics of the gastric antrum dysmotility in diabetic patients by 2D transabdominal ultrasound US imaging.
Навигация по записям
Patient selection: I0 patients with long standing diabetes mellitus and 10 healthy volunteers were enrolled to the study. The mean duration of the diabetes was 26 years. Inclusion criteria were: 1. Methods:The presence of autonomic neuropathy was established according to Ewing's criteria.
The mean autonomic neuropathy score was 5.
Impairment of the antral receptive relaxation in diabetic gastroparesis
For the US examinations a 3. Measurements were done before and 15, 30, 45, 60, 75, 90 minutes after the ingestion of a semisolid test meal 5g potato flakes in ml yogurt.
The figure shows that the antral area of the diabetic patients can diabetic gastroparesis be reversed significantly smaller popov a cukorbetegség kezelésében 30 minutes 9. These data demonstrate the impaired postprandial dilatation and the delayed emptying function of the gastric antrum.
Conclusions:Besides establishing the rate of gastric emptying, this US imaging protocol makes possible to detect the impairment of the postprandial receptive relaxation of the gastric antrum in diabetic patients. We consider this phenomenon as an important pathogenetic factor of the diabetic gastric motility disorder.
Mean antral area Fabielle L. The local mechanisms involved in gastroesophageal reflux have been poorly investigated so far in humans. Therefore, the aim of the present work was to assess the pharmacological and physiological significance of the responses of human lower oesophageal sphincter LES and lower oesophagus to neurostimulation NS and to cisapride.
Methods: Mechanical spontaneous activities and responses to nerve stimulation NS of LES and oesophageal muscle strips from 15 patients were carefully dissected in circular and longitudinal directions.
Results: Muscle strips developed spontaneous tone I to 5 g.
Ha a vércukor 12-re emelkedett
Only muscle strips from oesophagus developed spontaneous rhythmic contractions I cpm. Responses to NS consisted in a contraction followed by a relaxation in the oesophagus; a relaxation followed by a rebound contraction in the LES. Contractions were inhibited by atropine and after neurokinin A desensitisation; relaxations were partially reduced by L-NAME.
In oesophagus, cisapride I0p,M-2p,M did not altered spontaneous activities and reduced contractions induced by nerve stimulation. At doses 1p,M-O. However, at doses l p,MO.
Furthermore, RS, a 5HT4-receptor antagonist, prevented the increase of rebound contraction induced by cisapride at these doses. At lower doses, which are comparable to cisapride plasmatic levels in patients during treatment, cisapride seems to release acetylcholine and probably tachykinins, via 5HT4 receptors.
At higher doses, cisapride affects excitatory nerve activity as well as NANC inhibitory nerves Since